Introduction
Bacteria from clinical and non-clinical settings are becoming increasingly resistant to
conventional antibiotics. 10 years ago, concern centred on Gram-positive bacteria, particularly
meticillin-resistant Staphylococcus aureusand vancomycin-resistant Enterococcusspp. Now,
however, clinical microbiologists increasingly agree that multidrug-resistant Gram-negative
bacteria pose the greatest risk to public health. Not only is the increase in resistance of Gramnegative bacteria faster than in Gram-positive bacteria, but also there are fewer new and
developmental antibiotics active against Gram-negative bacteria and drug development
programmes seem insufficient to provide therapeutic cover in 1020 years.
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