Magnetic resonance imaging (MRI), with its lack of ionizing radiation and
capacity to provide exquisite anatomical detail, has revolutionized the study of
human brain development. Other imaging modalities such as conventional radiography, computerized tomography, positron emission tomography (PET), and single
photon emission computerized tomography (SPECT) use ionizing radiation. While
these latter techniques may be used with pediatric patient populations when
clinically warranted, the ethics of exposing children to radioactive isotopes for the
advancement of science are less clear (Casey and Cohen, 1996; Morton, 1996;
Zametkin et al., 1996). The advent of functional MRI has now further extended the
utility of MRI to explore the developing human brain as never before. This paper
aIDresses MRI studies of structural and functional changes in the developing
human brain and their relation to changes in cognitive processes over the first few
decades of human life.
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