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s views on the anti-cancer benefits of vitamin C megadoses correct after all? A r… Show more Were Linus Pauling’s views on the anti-cancer benefits of vitamin C megadoses correct after all? A recent Science report from the Cantley lab shows that the oxidized form of vitamin C, dehydroascorbic acid, (DHA) selectively kills colon cancer cells whose growth is “driven” by either KRAS (e.g., RasD) or BRAF (e.g., BRAFV600E) oncogenes. What enables DHA to be selectively targeted into these cancer cells and what explains its cytotoxicity? A. DHA is endocytosed into these cells after binding EGF receptors. DHA increases levels of cytosolic reduced glutathione (GSH) thereby reducing levels of reactive oxygen species (ROS). Reduced ROS inhibits glyceraldehyde 3-phosphate dehydrogenase (GAPDH), which in turn inhibits glycolysis and ATP production and results in cell death. B. DHA is selectively transported into these cells by overexpressed GLUT1 transporters. DHA depletes cytosolic reduced glutathione (GSH) generating reactive oxygen species (ROS) that inhibit glyceraldehyde 3-phosphate dehydrogenase (GAPDH), thereby inhibiting glycolysis and ATP production and resulting in cell death. C. DHA is transported into the cells by overexpressed GLUT1 transporters. DHA depletes cytosolic reduced glutathione (GSH) reducing levels of reactive oxygen species (ROS) thereby activating glyceraldehyde 3-phosphate dehydrogenase (GAPDH), which stimulates glycolysis and ATP production, resulting in cell death. D. DHA is endocytosed into these cells after binding EGF receptors. DHA depletes cytosolic reduced glutathione (GSH) thereby increasing levels of reactive oxygen species (ROS) which inhibits glyceraldehyde 3-phosphate dehydrogenase (GAPDH), which in turn inhibits glycolysis and ATP production and results in cell death. E. DHA is transported into the cells by overexpressed GLUT1 transporters. DHA depletes cytosolic reduced glutathione (GSH) generating reactive oxygen species (ROS) that inhibit the activities of both RasD and RafV600E resulting in cell death. • Show less60 Homework Help

s views on the anti-cancer benefits of vitamin C megadoses correct after all? A r… Show more Were Linus Pauling’s…

4 years ago

Introduction to health informatics: History, Current Status and Future of Electronic Health Records (& PCEHR) leading to “Big Data” for Healthcare Analytics in Clinical Decision Support Application. Homework Help

Introduction to health informatics: History, Current Status and Future of Electronic Health Records (& PCEHR) leading to “Big Data” for…

4 years ago

conscience clauses” and why are they a potential problem for female hospital patients at 1 in 6 hospitals in the US? BONUS: How do these women’s stories help explain this situation? Homework Help

conscience clauses” and why are they a potential problem for female hospital patients at 1 in 6 hospitals in the…

4 years ago

Psychology of AIDiction Homework Help

Psychology of AIDiction Psychology of AIDiction While the text authors do not advocate always beginning treatment with a full evaluation,…

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Students Against Violence and what causes bullying Homework Help

Students Against Violence and what causes bullying Students Against Violence and what causes bullying Bullying has been an ancient problem…

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Polycystic kidney (PK) disease in cats is an autosomal dominant disease that can lead to kidney fail… Show more Polycystic kidney (PK) disease in cats is an autosomal dominant disease that can lead to kidney failure and is usually not a problem until after cats are of breeding age or older. The gene that causes the disease is closely linked to 2 genetic markers on the same chromosome. The marker upstream of the disease gene is called the B locus and has four possible alleles: B1, B2, B3 and B4. The downstream marker is called the T locus and has 5 possible alleles: T1, T2, T3, T4 and T5. Mrs. FiIDlestix is worried that her prized Persian kitten, Fifi, may carry the disease gene because her sire, Phishy, recently died from the condition. Her dam, Coco, does not appear to have the disease and has no family history of the condition. Phishy also sired two other cats with another female (Boodles). One of the cats from that litter, Gretel (female), has the disease and the other cat, Hansel (male), shows no signs of the condition. Mrs. FiIDlestix had all the living cats genotyped at the B and T loci and has asked you to help her interpret the results. The genotypes for each individual are given below: Fifi: B1B4 T2T4 Coco: B1B3 T1T2 Gretel: B1B2 T1T3 Hansel: B1B4 T4T5 Boodles: B1B1 T1T5 a. Draw the pedigree, remembering to label all generations and individuals within each generation as learned in this class. b. Assume there is no crossing over between the B, T and PK loci. Does Fifi carry the gene that causes the PK disease? Explain why or why not. c. Draw the arrangement of the alleles for all members of the pedigree using CORRECT NOTATION • Show less60 Homework Help

Polycystic kidney (PK) disease in cats is an autosomal dominant disease that can lead to kidney fail… Show more Polycystic…

4 years ago

Cosmetic Surgery Is Beneficial To The Person Homework Help

Cosmetic Surgery Is Beneficial To The Person Cosmetic Surgery Is Beneficial To The Person Order Description Please include these info.…

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Introduction to Social Psychology Homework Help

Introduction to Social Psychology Introduction to Social Psychology Order Description Primary Task:Write 300 words that respond to the following questions…

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Prevention and Treatment Presentation Homework Help

Prevention and Treatment Presentation Category : Bold Essays Writing Prevention and Treatment Presentation This week you will identify current prevention…

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Psychology Cross-Cultural Perspectives on Ageing Homework Help

Psychology Cross-Cultural Perspectives on Ageing Task You will need to complete a series of short answer questions that pertain to…

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