Identification and analysis of DNA repair mechanisms that contribute to resistance against nucleoside analogues. Homework Help

Identification and analysis of DNA repair mechanisms that contribute to resistance against nucleoside analogues.
Referencing Requirements:
Blagosklonny, M. 2005, “Carcinogenesis, cancer therapy and chemoprevention”, Cell Death & Differentiation, vol. 12, no. 6, pp. 592- 602.
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novel genes and pathways involved in genome stability maintenance”, DNA repair, vol. 8, no. 5, pp. 672-679.
Evan, G.I. & Vousden, K.H. 2001, “Proliferation, cell cycle and apoptosis in cancer”, Nature, vol. 411, no. 6835, pp. 342-348.
Galmarini, C.M., Mackey, J.R. & Dumontet, C. 2002, “Nucleoside analogues and nucleobases in cancer treatment”, The lancet oncology, vol. 3, no. 7, pp. 415-424.
Galmarini, C.M., Warren, G., Kohli, E., Zeman, A., Mitin, A. & Vinogradov, S.V. 2008, “Polymeric nanogels containing the triphosphate form of cytotoxic nucleoside analogues show antitumor activity against breast and colorectal cancer cell lines”, Molecular cancer therapeutics, vol. 7, no. 10, pp. 3373.
Galmarini, C., Mackey, J. & Dumontet, C. 2001, “Nucleoside analogues: mechanisms of drug resistance and reversal strategies.”, Leukemia: official journal of the Leukemia Society of America, Leukemia Research Fund, UK, vol. 15, no. 6, pp. 875.
Glisson, B.S. & Ross, W.E. 1987, “DNA topoisomerase II: a primer on the enzyme and its unique role as a multidrug target in cancer chemotherapy”, Pharmacology & therapeutics, vol. 32, no. 2, pp. 89-106.
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???BSM-4109-0 Project Preparation 2012
???Järvinen, T., Kononen, J., Pelto-Huikko, M. & Isola, J. 1996, “Expression of topoisomerase IIalpha is associated with rapid cell proliferation, aneuploidy, and c-erbB2 overexpression in breast cancer.”, The American journal of pathology, vol. 148, no. 6, pp. 2073.
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Kantarjian, H., Gandhi, V., Cortes, J., Verstovsek, S., Du, M., Garcia-Manero, G., Giles, F., Faderl, S., O’Brien, S. & Jeha, S. 2003, “Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia”, Blood, vol. 102, no. 7, pp. 2379-2386.
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Page 17 of 18
???BSM-4109-0 Project Preparation 2012
???Pommier, Y., Leo, E., Zhang, H.L. & Marchand, C. 2010, “DNA topoisomerases and their poisoning by anticancer and antibacterial drugs”, Chemistry & biology, vol. 17, no. 5, pp. 421-433.
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